• ✅ Controlled molar substitution: 0.40-1.50 (actual 0.69), provides optimal inclusion performance
• ✅ Ultra-low residual impurities: ≤1.5% betadex (actual 0.32%), ≤2.5% propylene glycol (actual 0.11%)
• ✅ Extremely low propylene oxide: ≤0.0001% (actual 0.000002%), meets strict safety standards
• ✅ Low moisture content: ≤10.0% (actual 3.6%), prevents caking and improves stability
• ✅ Excellent water solubility: Freely soluble in water and propylene glycol, superior to native beta cyclodextrin
• ✅ High purity: No other single impurities detected, total impurities <1.0%
• ✅ Low conductivity: ≤200uS/cm (actual 42uS/cm), ideal for various industrial applications
• ✅ Excellent microbial control: Total aerobic count <10cfu/g, molds and yeasts <10cfu/g, no pathogens
• ✅ Versatile functionality: Improves solubility, stability and bioavailability of active ingredients
• ✅ Strict quality control: Batch-to-batch consistency guaranteed, full traceability from raw material to finished product

Hydroxypropyl Beta Cyclodextrin, commonly known as HPBCD or HP-β-CD, is a chemically modified derivative of beta cyclodextrin with CAS number 128446-35-5. It is produced by reacting beta cyclodextrin with propylene oxide under alkaline conditions, resulting in a product with significantly improved water solubility compared to native beta cyclodextrin.

The unique molecular structure of HPBCD features a hydrophobic internal cavity and a hydrophilic external surface with hydroxypropyl substituents, allowing it to form water-soluble inclusion complexes with a wide range of guest molecules. This property makes it an invaluable ingredient for improving the solubility, stability and bioavailability of poorly soluble active ingredients. It is extensively used in the food industry as a flavor encapsulant, in the cosmetic industry as an active ingredient carrier, and in various industrial applications.

Our HPBCD is manufactured with advanced production technology, with full batch traceability and complete supporting quality documents. We offer both standard grade and customized specifications with different molar substitution degrees to meet specific customer requirements and ensure long-term stable bulk supply for global manufacturers.

Appearance: White or almost white, amorphous or crystalline powder

Packaging: 25kg fiber drum with inner PE liner; 500kg big bag; Customized packaging available upon request

MOQ: 1 Metric Ton (25kg sample drum supported for testing and evaluation)

Storage Conditions: Store in tightly sealed containers in a cool, dry and well-ventilated warehouse at 5-30℃; Keep away from moisture, heat sources and incompatible materials; Avoid direct sunlight; 24-month shelf life under proper storage conditions

Transport Classification: Common chemical

• HPBCD
• HP-β-CD
• Hydroxypropyl-β-cyclodextrin
• Hydroxypropyl Betadex
• 2-Hydroxypropyl-β-cyclodextrin
• CAS 128446-35-5
• Industrial Grade Hydroxypropyl Beta Cyclodextrin
• Modified Cyclodextrin
• Solubilizing Agent HPBCD

1. Food & Beverage Industry (Core Application): Applied as food additive to encapsulate flavors, fragrances and vitamins, improving their stability and extending shelf life. Used to mask unpleasant tastes and odors in food products.
2. Cosmetic & Personal Care Industry: Used to encapsulate active ingredients such as essential oils, vitamins and antioxidants, improving their stability and skin penetration. Applied in skincare products, hair care products, perfumes and deodorants.
3. Pharmaceutical Industry: Used as excipient to improve solubility, stability and bioavailability of poorly soluble drugs. Applied in oral tablets, capsules and topical formulations. Also used for drug delivery systems and controlled release formulations.
4. Environmental Industry: Used for removal of organic pollutants, heavy metals and pesticides from water and soil. Forms inclusion complexes with contaminants, facilitating their removal and degradation.
5. Industrial Applications: Employed in textile processing, paper manufacturing, printing inks and chemical synthesis. Used as chiral selector in chromatography and as catalyst in organic reactions.
6. Agricultural Industry: Applied as encapsulation agent for pesticides and fertilizers, improving their stability, reducing volatility and extending efficacy.

A1: Molar substitution is the average number of hydroxypropyl groups per glucose unit in the cyclodextrin molecule. It ranges from 0.40 to 1.50 for HPBCD. Higher MS values result in better water solubility but may reduce inclusion capacity. Our standard grade has an MS of 0.69, which provides an optimal balance between solubility and inclusion performance.

A2: HPBCD has significantly higher water solubility (>50g/100mL at 25℃) compared to native beta cyclodextrin (18.5g/100mL at 25℃). It also has lower toxicity and better biocompatibility, making it suitable for a wider range of applications.

A3: Yes, HPBCD is generally recognized as safe (GRAS) by the FDA and is approved for use as a food additive and cosmetic ingredient in most countries worldwide. It has low toxicity, is non-irritating and is rapidly excreted from the body unchanged.

A4: The recommended usage level varies depending on the application:

• Food and beverages: 0.1-5.0%
• Cosmetics and personal care: 0.5-10.0%
• Pharmaceutical formulations: 1.0-40.0%

The exact concentration should be determined based on the specific active ingredient and desired effect.

A5: Common methods for preparing inclusion complexes include:

• Co-precipitation method: Dissolve HPBCD in water, add guest molecule, stir and cool to precipitate the complex
• Kneading method: Mix HPBCD with guest molecule and small amount of water to form a paste, then dry
• Freeze drying method: Dissolve both components in water, then freeze dry to obtain the complex
• Spray drying method: Suitable for large-scale industrial production

A6: HPBCD has a shelf life of 24 months when stored in tightly sealed original containers under proper storage conditions. It is hygroscopic and will absorb moisture from the air, which can cause caking. Keep containers tightly closed when not in use and store in a dry place.